Mediation analysis reveals the mediation role of the skin microbiome. Only models that had consistent mediation effects are contained in the table. Each model contains three variables (X, exposure; M, mediator; and Y, outcome). Each number in the table represents the coefficient of each path (a, X to M; b, M to Y; c, X to Y; total, total effect a*b+c; mediation, mediation effect a*b). Red numbers indicate significant coefficients with a negative value, black numbers indicate significant coefficients with a positive value, and gray numbers indicate nonsignificant coefficients.