Fig. 8. Representation of some of the diverse phenols that are accepted as non-natural substrates by different wild-type halogenases. All experiments are in vitro, unless specified otherwise, and % conversions reported as determined by LC/LC-MS. Enzymes include (A) chloroperoxidase (heme iron-dependent),^156–158 (B) bromoperoxidase (vanadium-dependent)¹⁵⁹ (C and D) AmVHPO (vanadium-dependent)¹⁰⁷ (E) RadH (FDH) chlorination;¹⁴⁴ (F) Rdc2 (FDH) chlorination and bromination;^143,160 (G) RebH (FDH) chlorination¹²⁶ (H and I) Bmp5 brominase (FDH) in vivo.⁴⁵ (J) PltM (FDH) associated with transcriptional regulation of pyoluteorin 43 biosynthesis,^51,161 (K) VirX1 (FDH from a virus, the first FDH with a preference for iodination).⁴⁷ Chlorination, bromination and iodination are colour coded blue, red and purple respectively.