Scheme 8. Installation of halogen on protein-tethered aliphatic substrate performed selectively by a NHFeHals, in the biosynthesis of natural products, enabling alkene generation and cyclopropane generation. (A) Jamaicamide 204,61 (B) curacin A 208,174 (C) coronatine 213,175 and (D) kutzneride 29.118 Notable similarities may be observed between the first steps in jamaicamide, vinylchloride formation and curacin cyclopropyl biosynthesis. Coronamic acid and kutzneride 29 biosynthesis are initiated by the halogenation of the γ-methyl of different diastereoisomers of l-isoleucine.
