Classification	Enzymes	No. residuesb	PDB code	Cofactors and ligands	Idt. time	Relevant BGC	Oligomer	Reported substrates	Halogen	Source	Ref.
Vanadium-dependent haloperoxidases	Ci-VCPO	609	1VNC	VO4, AZI	1996	—	Monomer	Chlorinated 1-(4-ethoxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-1,3-dihydroxypropane	Cl, Br	Curvularia inaequalis	97
			1VNS	SO4	1999						98
			1VNI	Apo form							98
			1VNH (H496A)	VO4							98
			1VNG (H404A)	VO4							98
			1VNF (R360A)	VO4		—					98
			1VNE (D292A)	VO4							98
			1IDQ	VO4	1997	—					99
			1IDU	VO4		—					99
			3BB0	PO3	2008						100
	An-VBPO1	556	1QI9	VO4, I−	1999	—	Dimer	2-Methylindole, 2-phenylindole, phenolsulfonephthalein, derivatives of O-methyl pyrrole-2-carboxylate	Br, I	Ascophyllum nodosum	101–103
	An-VBPO2	597	5AA6	VO4	2015	—	Hexamer	Refer to An-VBPO1	Br, I	Ascophyllum nodosum	TBP
	Co-VBPO	596	1QHB	PO4	1999	—	Dodecamer	(E)-(+)-Nerolidol	Br	Corallina officinalis	104
	Cp-VBPO	598	1UP8	PO4	2005	—	Dodecamer	c	Br	Corallina pilulifera	105
	NapH1	531	3W35 (Apo form)	—	2012	Napyradiomycin	Dimer	Polyketide-terpenoid substrates	Cl, Br	Streptomyces sp. CNQ525	TBP
			3W36	VO4	2012						TBP
	Zg-VIPO1	458	4CIT	VO4	2014	—	Monomer	TB iodoperoxidase assay	I	Zobellia galactanivorans	106
	Zg-VIPO2	458	4USZ	VO4	2014	—	Monomer	TB iodoperoxidase assay	I	Zobellia galactanivorans	106
	AmVHPO	639	5LPC	PO4	2016	—	Dodecamer	Aromatic substrates	Cl, Br	Acaryochloris marina	107
Heme-dependent haloperoxidases	HI-HPO	373	1CPO	HEM	1995	Caldariomycin	Monomer	1,3-Cyclopentanedione, electron-rich aromatic substrates	Cl, Br	Leptoxyphium fumago	108
			2CPO	HEM							108
			2CJ0	HEM	2006						109
			2CIW	HEM, I−							109
			2CIV	HEM, Br−							109
			2CJ2	HEM, FMT							109
			2CJ1	HEM, FMT							109
			2CIZ	HEM, Br−							109
			2CIY	HEM, Br−, CYN, DMSO							109
			2CIX	HEM, CEJ, Br−, EDO							109
NHFe dependent halogenases (NHFeHal)	CytC3	319	3GJA	ACT	2009	γ,γ-Dichloroaminobutyrate	Monomer	l-2-Aminobutyric acid	Cl	Streptomyces sp.	110
			3GJB	AKG, ACT, Fe2+							110
	SyrB2	310	2FCT	DSU, AKG, Cl−, Fe2+	2006	Syringomycin E	Monomer	l-Threonine	Cl, Br	Pseudomonas syringae	111
			2FCV	DSU, AKG, Br−, Fe2+							111
			2FCU	DSU, AKG							111
	CurA-Hal	2311	2LIU	—	2011	Curacin A	Domain (NMR structure)	3-Hydroxyl-3-methyl-glutaryl	Cl	Lyngbya majuscula	111
			2LIW	PNS, MAH	2011		Domain (NMR structure)				111
	WelO5	315	5IQS	AKG, Fe2+, Cl−	2016	Welwitindoline	Monomer	12-Epi-fischerindole U	Cl, Br	Hapalosiphon welwitschii	111
			5IQT	6CU, AKG, Fe2+, Cl−							111
			5IQU (G166D)	6CU, AKG, Fe2+							111
			5IQV	6CU, AKG, Fe2+, Cl−, NO							111
			5J4R	AKG, Ni2+	2016						TBP
			5T22	AKG, Ni2+	2016						TBP
			5TRQ	SIN, ACT, Ni2+	2016						TBP
SAM (S-adenosyl-l-methionine)-dependent halogenases	FIA	299	1RQP	SAM	2004	d	Hexamer	SAM	F	Streptomyces cattleya	67
			1RQR	5FD, MET							67
			2C2W	5CD, Cl−	2005						68
			2C4T	SA8, Cl−	2007						TBP
			2C4U	—	2006						112
			2C5B	5F1, MET							112
			2CBX	CC5							112
			2CC2	—							112
			2C5H	3D1, MET, Cl−	2006						TBP
			2V7T (S158G)	SAH, Cl−	2008						87
			2V7U (S158G)	SAM, Cl−							87
			2V7V	5FD							87
			2V7W (S158G)	5FD							87
			2V7X (S158G)	5FD, MET							87
			4CQJ	EFA	2014						TBP
			5FIU	Y3J, TLA	2015						113
			5LMZ	1DA, Cl−	2016						114