Table 1.

Effects of SAX and VIL on renal functions in DXR-induced nephrotoxicity. Data are presented as mean ± SEM, n = 10. Rats of the normal control group received intraperitoneal saline.

Groups	Creatinine (mg/dL)	BUN (mg/dL)
Normal control	0.71 ± 0.01	25.67 ± 0.45
DXR-control (15 mg/kg, i.p)	1.58a ± 0.05	49.11a ± 1.68
DXR + SAX (10 mg/kg, p.o.)	1.08ab ± 0.06	36.77ab ± 1.48
DXR + VIL (10 mg/kg, p.o.)	0.83b ± 0.05	30.53b ± 0.78

DXR, Doxorubicin; SAX, saxagliptin; VIL, vildagliptin; ^aP < 0.05 indicates significantly differences compared to the normal control group and ^bP < 0.05 versus DXR-control group.