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. 2001 Apr 23;2001(2):CD003098. doi: 10.1002/14651858.CD003098

Westergaard 1983.

Methods Allocation: sealed envelopes. 
 Blinding: None described. 
 Study period: 24 months, specific dates not stated.
Participants Inclusion criteria: women admitted for induction of labor with single live fetus in cephalic position and membranes intact. 
 Setting: University hospital, Odense, Denmark.
Interventions Women with unfavorable cervix (n = 264): oral PGE2 0.5 mg increasing to 1.5 mg per hour if needed (n = 133) vs demoxytocin 50 IU every 1/2 hour (n = 131).
Women with favorable cervix underwent amniotomy (n = 259 of which 136 progressed into labour within 4 hours without medication). The remaining 123 women received oral PGE2 as above (n = 48) vs demoxytocin as above (n = 75).
Outcomes Induction failure (defined as lack of regular contractions and cervical dilatation of 5 cm within 48 hours or 8 hours of spontaneous or artificial rupture of membranes). 
 Treatment time. 
 Duration of labor. 
 Apgar score < 7. 
 Mode of delivery. 
 Gastrointestinal side‐effects. 
 Uterine hypertonus.
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Low risk A ‐ Adequate