| Study | Reason for exclusion |
|---|---|
| Adams 1981 | Comparative trial between antifibrinolytic agents and blood pressure reduction or fluid restriction |
| Ameen 1981 | Not a randomised trial; historic control group used |
| Brzecki 1974 | All participants received epsikapron, while being randomised between trasylol or placebo; also historical control group |
| Buchner 1985 | Not a randomised trial; historical control group |
| Chowdhary 1979 | Not strictly randomised; allocation to treatment or placebo according to days of the week |
| Chowdhary 1981 | Comparative trial between tranexamic acid and EACA |
| Chowdhary 1986 | No clinical outcome reported, only data on rebleeding and cerebral ischaemia |
| Fodstad 1978 | No ITT analysis possible; too many participants (14 of a of total 60 randomised) excluded from final analysis after randomisation |
| Gelmers 1980 | Not strictly randomised; allocation to treatment or placebo according to days of the week |
| Gibbs 1971 | Not a randomised trial; significant treatment differences, for instance concerning the timing of surgery, between the EACA‐treated participants and the control group |
| Kassell 1984 | Not a randomised trial; case‐control study |
| Knuckey 1982 | Not a randomised trial; case‐control study |
| Marchel 1992 | Not a randomised trial; historic control group used |
| Nibbelink 1975 | Not a randomised trial, no control group |
| Profeta 1975 | Not a randomised trial; historic control group used |
| Rosenorn 1988 | Not a randomised trial; case‐control study |
| Salaschek 1983 | Not a randomised trial; historical control group |
| Sengupta 1976 | Not a randomised trial; physicians preferred allocation |
| Shucart 1980 | Not a randomised trial; physicians preferred allocation |
| Starke 2008 | Not a randomised trial; case control study |
| Wijdicks 1989 | Not a randomised trial; case‐control study with historical control group |
EACA: epsilon amino‐caproic acid ITT: intention‐to‐treat