Figure 6.

Induced CXCR6⁺CD8⁺ T cells inhibit tumor growth in mouse model. (A) Schematic diagram showing treatment using CXCR6⁺CD8⁺ T cells induced in vitro. Mice were inoculated subcutaneously with MC38 tumor cells. A week later, tumor load mice were treated with CXCR6^-CD8⁺ T or CXCR6⁺CD8⁺ T cells that were induced in vitro and isolated by FACS. (B). Tumor growth (n=9–11). (C). Schematic diagram showing treatment using OT-I ⁺CXCR6⁺ CTL induced in vitro. OT-I and CXCR6^−/− mice were crossed to obtain CXCR6^−/− OT-I mice. SIINFEKL pulsed T cells were stimulated by IL-2 and then were injected into B16OVA tumor load mice by tail vein. (D) Tumor growth (n=10–11). (E) Survival curves of tumor burden mice. (F) Images of tumors. (G) Tumor growth (n=10). (H) Representative plots showing the ratio of CD8⁺ T cells in each group. *P<0.05 and **p<0.01.