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Closer insight into CAR-macrophage activation and anticancer mechanisms. The binding of tumor antigen with the respective recognition site in the CAR receptor on the surface of CAR-macrophages generates activation signals that mediate tumor phagocytosis, activation of transcription factors such as NF-kB and subsequent release of inflammatory cytokines, which in turn can activate T cell-mediated immunity against the tumor. CAR, chimeric antigen receptor.
