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. 2021 Aug 24;13(4):402–409. doi: 10.5114/jcb.2021.108594

Table 3.

Comparison of our and literature results on salvage oral and oropharyngeal brachytherapy

Author, year [ref.] Number of patients Tumor site Tumor stage Previous RT dose (median) Surgery Chemotherapy RT technic (n) Total dose
(median)
Local control OS
(5 years)
Side effects ≥ grade 3
Mazeron et al., 1987 [12] 70 Oropharynx T1: 23
T2: 35
T3: 12
N.A. No
No LDR 60 to 65 Gy (60.0) 72%/2 y
69%/5 y
14% Acute and late: 27%
1 patient – grade 5
Levendag et al., 1991 [16] 18 Oral cavity/oropharynx N.A. 40 to 70 Gy (60) Salvage surgery: 5 Chemotherapy: 3 LDR (n = 11)
LDR + EBRT (n = 7)
35 to 95 Gy (60.6) 50%/5 y 20% Acute: 36%
Late: 28%
Peiffert et al., 1994 [13] 73 Oropharynx T1: 45
T2: 20
T3/TX: 8
N.A. No No LDR 50 to 75 Gy (60.3) 78%/4 y 30% 0%
Strnad et al., 2014 [14] 51 Oral cavity/oropharynx T1: 5
T2: 23
T3: 8
T4: 6
TX: 0
60 to 76 Gy (65) No Concomitant chemotherapy: 35 PDR (n = 40)
PDR + EBRT (n = 11)
BT dose, 12 to 66.3 Gy (57.0) 57%/5 y 26% Acute: 10%
Late: 18%
Bhalavat et al., 2018 [15] 25 Oral cavity/oropharynx N.A. 66 Gy No No HDR (n = 18)
HDR + EBRT (n = 7)
40.5 Gy
27.0 Gy
84%/1 y
75%/2 y
Na Late: 2%
The present study 25 Oral cavity/oropharynx T1: 7
T2: 11
T3: 3
T4: 1
TX: 3
50 to 72 Gy (65) Salvage surgery: 22 Chemotherapy: 4 LDR/PDR (n = 15)
LDR/PDR + EBRT (n = 10)
40 to 70 Gy (57.0) 75%/2 y 26% Acute: 16%
Late: 0%

BT – brachytherapy, EBRT – external beam radiotherapy, LDR – low-dose-rate, HDR – high-dose-rate, PDR – pulsed-dose-rate, RT – radiotherapy, OS – overall survival, N.A. – not applied