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Forest plots for late grade ≥ 3 genitourinary (GU) and gastrointestinal (GI) toxicity rates with corresponding 95% confi- dence intervals in 11 individual study groups, and the combined estimate using a random-effects model. The pooled estimate of late grade ≥ 3 GU toxicity rate was 0.03% (95% CI: 0.02-0.05%, p-value < 0.001). The pooled estimate of late grade ≥ 3 GI toxicity rate was 0.0002% (95% CI: –0.001-0.001%, p-value = 0.743)
