Comparison 2. High‐dose colchicine versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Proportion with 50% or greater decrease in pain score from baseline	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1.1 12 hours	1	43	Risk Ratio (M‐H, Random, 95% CI)	2.39 [0.52, 10.99]
2.1.2 24 hours	2	124	Risk Ratio (M‐H, Random, 95% CI)	2.88 [1.28, 6.48]
2.1.3 32 to 36 hours	2	124	Risk Ratio (M‐H, Random, 95% CI)	2.16 [1.28, 3.65]
2.1.4 48 hours	1	43	Risk Ratio (M‐H, Random, 95% CI)	1.91 [1.05, 3.49]
2.1.5 Last time point	2	124	Risk Ratio (M‐H, Random, 95% CI)	1.97 [1.20, 3.24]
2.2 Proportion with 50% or greater decrease in inflammation from baseline	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
2.2.1 12 hours	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
2.2.2 24 hours	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
2.2.3 36 hours	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
2.2.4 48 hours	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
2.3 Total adverse events	2	124	Risk Ratio (M‐H, Random, 95% CI)	3.21 [2.01, 5.11]
2.4 Gastrointestinal adverse events (diarrhoea, vomiting or nausea)	2	124	Risk Ratio (M‐H, Random, 95% CI)	3.81 [2.28, 6.38]
2.5 Serious adverse events	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.6 Withdrawals due to adverse events	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only