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The XBP1s-dependent 12-h pacemaker is separate from the BMAL1-dependent circadian clock in the mouse. Heatmap illustrating 12-h hepatic transcriptome (upper) and core circadian clock TFs circadian expression (lower) in wild-type, XBP1 liver-specific knockout [6], and BMAL1-knockout ex vivo liver slices [30]. Chromatin binding of XBP1s [6] and BMAL1 [12] on the proximal promoter regions of these genes are shown on the right
