| Methods |
Randomised controlled trial. Randomisation by random numbers. Double‐blinded. Unclear blinding of outcome assessor. |
| Participants |
400 eligible patients. 117 excluded after randomisation. 283 enrolled in the study.
All patients above 12 years of age.
Patients already receiving antibiotics or steroids, diabetic and preoperative diagnosis of perforated appendix, were excluded before randomisation.
The study has 4 subgroups (see Chiam 1983 A & B).
In Chiam 1983 C 134 patients enrolled in the study. |
| Interventions |
Treatment group: Cotrimoxazole 2 ml i.m preoperatively and twice daily for 3 days
Placebo group: Not specified, regime as above. |
| Outcomes |
Wound infection (Pus in the main wound). |
| Notes |
Patients with the operative diagnosis of perforated appendix were included in study.
No comments on drain treatment. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Low risk |
A ‐ Adequate |
