| Methods |
Randomised controlled trial. Randomisation by random numbers.
Double‐blinded |
| Participants |
426 eligible patients. 20 patients were excluded after randomisation. 406 patients enrolled in the study. Age‐range 5‐>50.
Patients with allergy to metronidazol, pregnant women, patients with blood dyscrasia, active disease of the central nervous system or alcoholism were excluded before randomisation. |
| Interventions |
Treatment group: Metronidazole 500 mg = 100 ml i.v preoperatively.
Placebo group: 100 ml saline i.v preoperatively. |
| Outcomes |
Wound infection (Superficial accumulation of pus requiring surgical drainage).
Postoperative intraabdominal abscess (Pyrexia, postoperatively for more than 72 hours, and for wich all other causes could be excluded; Abdominal tenderness or distension; Discharge of pus per rectum). |
| Notes |
No drain treatment. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Low risk |
A ‐ Adequate |
