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. 2005 Jul 20;2005(3):CD001439. doi: 10.1002/14651858.CD001439.pub2

Griffiths 1976.

Methods Randomised controlled trial. Randomisation method not stated. 
 Triple‐blinded.
Participants 28 enrolled in the study. 
 Patients with antibiotic treatment prior to surgery, pregnant women, or impaired renal function were excluded before randomisation. 
 Patients with perforated appendix were excluded after randomisation.
Interventions Treatment group: Tobramycin 1,5 mg and Lincomycin 600 mg in 500 ml saline i.v peroperatively. 
 Placebo group: No treatment
Outcomes Wound infection (Severe: Purulent discharge, cultures positive for potential pathogens; Mild: Erythema, scanty pus, cultures positive; Colonised: Not clinical infected, cultures positive).
Notes Treatment beginning at the time of skin incision .
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear