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. 2005 Jul 20;2005(3):CD001439. doi: 10.1002/14651858.CD001439.pub2

Söderquist 1995 A.

Methods Randomised controlled trial 
 Randomisation method not stated
Participants 857 eligible patients. 313 patients excluded after randomisation. 
 544 patients enrolled in study. Alle children. 
 Patients with perforated appendicitis were excluded. Patients allergic to antibiotics or recieving antibiotic within 72 hours before surgery were excluded. 193 patients received treatment compared to 176 in the control group
Interventions Treatment group: metronidazole 20 mg/ kg IV 1 hour preoperatively. 
 Placebo group: No treatment
Outcomes Wound infection (subcutaneus abscess with suppuration confirmed by spontaneus wound rupture debriemnt or incision) 
 Intrabadominal absces (absces within the intraabdominal cagvity diagnosed at operation or by rectal examination, x‐ray or ultrasound)
Notes No comment on drain treatment
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear