Solish 2018.

Study characteristics
Methods	Study design‐ multicentre, randomised, dose‐ranging placebo‐controlled, parallel‐design in glabellar lines (BELMONT STUDY). Phase II Study date‐ no information Study setting‐ outpatients
Participants	Randomised 268 participants aged 30‐65 years of age. Gender: 80% of participants were female Incluion criteria: no information Exclusion criteria : no information Ethinicity‐ 85% were "white" Severity of the disease: moderate‐to‐severe glabellar lines
Interventions	Duration: from 24 weeks to 36 weeks Intervention DaxibotulinumtoxinA 20U, 40 U, 60 U in the glabellar lines Comparator OnabotulinumtoxinA 20 U in the glabellar lines Placebo in the glabellar lines Ratio: (1:1:1)
Outcomes	Primary outcome Proportion of participants with 1 grade change in GL severity at week 24. Secondary outcomes Responders at weeks 4 and 24 for the primary endpoint Proportion of participants with none/mild GL at these time point Adverse events
Notes	Poster
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "The BELMONT study was a randomized, "....page S106 Comment: we considered this unclear risk of bias because the authors did not explain how they randomised the participants
Allocation concealment (selection bias)	Unclear risk	Quote: "The BELMONT study was a randomized, "....page S106 Comment: we considered this unclear risk of bias because the authors did not explain how they randomised the participants
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Quote: "The BELMONT study was a randomized, "....page S10 Comment: we considered this unclear risk of bias because the authors did not explain how they blinded the participants
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Quote: "The BELMONT study was a randomized, "....page S10 we considered this unclear risk of bias because the authors did not explain how theey keep the participants blinded
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Quote: no information Comment: we consider an unclear risk of bias
Selective reporting (reporting bias)	Unclear risk	The authors did not show all the endpoints Comment: we consider an unclear risk of bias
Other bias	Unclear risk	This study is a poster