4. The frequencies of adverse events in toremifene and tamoxifen groups.

Adverse events	No. of studies %	TOR group		TAM group		P value
		No.	%	No.	%
Hot flushes	4	190	17.8	103	15.2	0.58
Sweating	3	48	7.6	39	8.5	0.82
Nausea	3	97	10.1	52	9.2	0.71
Voice changes	0	‐	‐	‐	‐	‐
Vaginal discharge	3	79	8.2	42	7.4	0.84
Vaginal bleeding	4	22	2.1	33	4.9	0.23
Vaginal dryness	0	‐	‐	‐	‐	‐
Vomiting	3	22	2.3	8	1.4	0.28
Headache	2	1	0.2	8	3.1	0.02
Thromboembolic events	4	30	2.8	27	4.0	0.47
Cardiac events	4	16	1.5	16	2.4	0.29
Ocular disorders	3	8	1.3	14	3.0	0.10
Endometrial cancer	3	0	0	4	0.9	0.10

TAM: tamoxifen
TOR: toremifene