| Methods |
"random allocation"
double blind double dummy
Duration: 6 weeks
Follow up: 100% |
| Participants |
healthy subjects
male / female: 17 / 33
Av Age: 33, SD 9
Smoking status not stated. |
| Interventions |
5 groups, each n=10; oral prednisolone 10mg or 40mg daily; inhaled budesonide 3.2mg or 0.8mg daily; or placebo; ethics committee stipulation that participants to be on a calcium restricted diet. |
| Outcomes |
measured at 1 week; serum osteocalcin;
calcium, phosphate, creatinine, alk.phos.,24hr urinary Ca, Pi & creatinine; i‐PTH; 1,25‐(OH)2D3; cortisol; urinary hydroxyproline; urinary cAMP; |
| Notes |
Jadad score 4. pill counting + inhaler weights to assess compliance. Authors provided raw data from the end of week one before cross‐over for inclusion in meta‐analysis. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Low risk |
A ‐ Adequate |
