McMillan 1995.

Methods	Randomized Multicenter Blinding of randomization: Yes (opaque, sealed envelopes) Blinding of intervention: Yes (Drug administration team) Complete Follow‐up: Short term: Yes Long term: 93% Blinding of outcome measurement: Yes Stratification: Based on birthweight and gender. Longterm Follow‐up: Saigal 1995, Courtney 1995
Participants	Neonates Birthweight 750‐1249 grams Respiratory distress syndrome Assisted ventilation a/A ratio <0.22 Age 2‐24 hours Infants Randomized: Exosurf Neonatal = 176 Control = 168
Interventions	Intratracheal Exosurf Neonatal (5 ml/kg) or sham treatment (air) Second dose 12 hours later if infant remained on assisted ventilation
Outcomes	PRIMARY OUTCOME: Survival without bronchopulmonary dysplasia at 28 days SECONDARY OUTCOME cardiorespiratory support complications of prematurity
Notes	Primary outcomes (survival without BPD), BPD and neonatal mortality reported based on intention to treat. Other complications of prematurity reported based on treatment received.