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. 2021 Aug 20;41(5):516–524. doi: 10.1097/JCP.0000000000001465

FIGURE 1.

FIGURE 1

Least squares mean (95% CI) treatment difference of change in the MADRS total score from baseline to 24 hours after the first dose by subgroupa. a Change in the MADRS total score was analyzed using ANCOVA with LOCF. Negative change in score indicates improvement. Patients were hospitalized at the time of the primary end point; therefore, missing data were infrequent. b Includes patients who had their dose reduced because of tolerability issues. c One patient in the esketamine 84 mg + standard-of-care group had missing MADRS data at baseline. One additional patient in esketamine 84 mg + standard-of-care group was missing both the day 1, 4 hour, and day 2 values and therefore was excluded from subgroup analyses.