Study	Reason for exclusion
Bartlett 1957	Meprobamate ‐ Two trials: 1st a cross‐over trial comparing it with lobeline and placebo. 2nd comparing meprobamate and placebo, to be taken when withdrawal symptoms were felt by subjects. There were 16 subjects and no indication of the follow up period was given
Carrão 2007	Buspirone ‐ Pharmacotherapy was combined buspirone and sertraline, vs placebo, as adjunct to cognitive behavioural therapy. Effect of buspirone could not be separated.
Farebrother 1980	Propanolol ‐ short follow up 40mg x3/day for 8 wks vs placebo, subjects advised to try to quit after 1 wk of treatment
Gawin 1989	Buspirone ‐ open trial
Hatsukami 2003	Granisetron ‐ short‐term study of withdrawal symptoms during 15 days of abstinence
Hilleman 1992	Buspirone ‐ short follow up 15mg/day for 1 wk, 30mg/day for 3 wks. Abstinence at 7 days post‐cessation.
Ionescu 2008	Buspirone ‐ Pharmacotherapy was combined buspirone and sertraline, vs placebo, as adjunct to cognitive behavioural therapy. Effect of buspirone could not be separated.
Robinson 1991	Buspirone ‐ case series
Robinson 1992	Buspirone ‐ short follow up Buspirone 30mg/day beginning 3 wks before abrupt cessation. Abstinence assessed 2 wks after quit day.
West 1991	Buspirone ‐ short follow up
West 1996	Ondansetron ‐ short follow up 0.25 mg/day 2 wks before and 4 wks after quit date
Zacny 1993	Ondansetron ‐ Crossover trial of smoking behaviour in an inpatient laboratory