Source	Search strategy	Hits retrieved
VASCULAR REGISTER IN CRSW	#1 Varicose Veins AND INREGISTER #2 foam AND INREGISTER #3 mechanochemical endovenous ablation AND INREGISTER #4 MOCA AND INREGISTER #5 sclerotherapy AND INREGISTER #6 sclerosing solutions AND INREGISTER #7 Laser AND INREGISTER #8 Ablation AND INREGISTER #9 Mechanochemical Ablation AND INREGISTER #10 Cyanoacrylates AND INREGISTER #11 steam AND INREGISTER #12 #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 #13 #1 AND #12	9 Jan 2018: 209
CENTRAL Issue 12, 2017	#1 MESH DESCRIPTOR Varicose Veins EXPLODE ALL TREES 809 #2 MESH DESCRIPTOR Venous Insufficiency EXPLODE ALL TREES 406 #3 (varic* or incomp* or insuffici* or tortuous or sapheno* or GSV or CVI):TI,AB,KY 24143 #4 #1 OR #2 OR #3 24177 #5 MESH DESCRIPTOR Laser Therapy EXPLODE ALL TREES 3510 #6 MESH DESCRIPTOR Catheter Ablation EXPLODE ALL TREES 1237 #7 (endovenous or EVLA or EVLT or radiofrequency or laser* or ablation* or obliteration* or RFA):TI,AB,KY 17365 #8 NBCA:TI,AB,KY 13 #9 (Mechanochemical endovenous Ablation):TI,AB,KY 6 #10 (Mechanochemical Ablation):TI,AB,KY 8 #11 #5 OR #6 OR #7 OR #8 OR #9 OR #10 17417 #12 MESH DESCRIPTOR Sclerotherapy EXPLODE ALL TREES 448 #13 MESH DESCRIPTOR Sclerosing Solutions EXPLODE ALL TREES 385 #14 sclero*:TI,AB,KY 10391 #15 (tetradecyl near2 (sulfate or sulphate)):TI,AB,KY 63 #16 MESH DESCRIPTOR Sodium Tetradecyl Sulfate EXPLODE ALL TREES 37 #17 MESH DESCRIPTOR Saline Solution, Hypertonic EXPLODE ALL TREES 446 #18 MESH DESCRIPTOR Ethanolamines 1503 #19 (polydocanol or polidocanol):TI,AB,KY 217 #20 saline:TI,AB,KY 20996 #21 (ethanolamine near2 oleate):TI,AB,KY 66 #22 (sodium near2 morrhuate):TI,AB,KY 19 #23 sotradecol:TI,AB,KY 6 #24 (aetoxisclerol or aethoxysclerol):TI,AB,KY 15 #25 (aetoxiskerol or aethoxyskerol):TI,AB,KY 1 #26 Turbofoam:TI,AB,KY 2 #27 (foam* or microfoam*):TI,AB,KY 1464 #28 varisolve:TI,AB,KY 2 #29 #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25 OR #26 OR #27 OR #28 34198 #30 MESH DESCRIPTOR Cyanoacrylates EXPLODE ALL TREES 181 #31 ("tissue adhesive*"):TI,AB,KY 730 #32 Cyanoacrylate*:TI,AB,KY 317 #33 Enbucrilate:TI,AB,KY 83 #34 VenaSeal:TI,AB,KY 3 #35 VariClose:TI,AB,KY 0 #36 VeClose:TI,AB,KY 5 #37 Histoacryl:TI,AB,KY 39 #38 #30 OR #31 OR #32 OR #33 OR #34 OR #35 OR #36 OR #37 905 #39 MOCA:TI,AB,KY 278 #40 ClariVein:TI,AB,KY 9 #41 #39 OR #40 284 #42 (Endovenous steam):TI,AB,KY 1 #43 steam:TI,AB,KY 186 #44 #42 OR #43 186 #45 #11 AND #19 34 #46 #11 AND #38 50 #47 #11 AND #41 16 #48 #11 AND #44 16 #49 #29 AND #38 70 #50 #29 AND #41 17 #51 #29 AND #44 11 #52 #38 AND #41 1 #53 #38 AND #44 0 #54 #41 AND #44 1 #55 #45 OR #46 OR #47 OR #48 OR #49 OR #50 OR #51 OR #52 OR #53 OR #54 184 #56 #4 AND #55 95	9 Jan 2018: 95
Clinicaltrials.gov	Varicose Veins | steam OR ablation OR sclerotherapy OR Cyanoacrylates OR GLUE OR foam	9 Jan 2018: 99
ICTRP Search Portal	Varicose Veins | steam OR ablation OR sclerotherapy OR Cyanoacrylates OR GLUE OR foam	9 Jan 2018: 68
MEDLINE 2017 and 2018 only	1 exp Varicose Veins/ 17950 2 exp Venous Insufficiency/ 7467 3 (varic* or incomp* or insuffici* or tortuous or sapheno* or GSV or CVI).ti,ab. 454946 4 or/1‐3 464353 5 exp Laser Therapy/ 61085 6 exp Catheter Ablation/ 31949 7 (endovenous or EVLA or EVLT or radiofrequency or laser* or ablation* or obliteration* or RFA).ti,ab. 347334 8 NBCA.ti,ab. 475 9 "Mechanochemical endovenous Ablation".ti,ab. 21 10 "Mechanochemical Ablation".ti,ab. 25 11 or/5‐10 364051 12 exp Sclerotherapy/ 5483 13 exp Sclerosing Solutions/ 10961 14 sclero*.ti,ab. 185374 15 (tetradecyl adj2 (sulfate or sulphate)).ti,ab. 461 16 exp Sodium Tetradecyl Sulfate/ 461 17 exp Saline Solution, Hypertonic/ 5748 18 Ethanolamines/ 11982 19 (polydocanol or polidocanol).ti,ab. 770 20 saline.ti,ab. 173305 21 (ethanolamine adj2 oleate).ti,ab. 337 22 (sodium adj2 morrhuate).ti,ab. 179 23 sotradecol.ti,ab. 54 24 (aetoxisclerol or aethoxysclerol).ti,ab. 50 25 (aetoxiskerol or aethoxyskerol).ti,ab. 1 26 Turbofoam.ti,ab. 2 27 (foam* or microfoam*).ti,ab. 24095 28 varisolve.ti,ab. 2 29 or/12‐28 403167 30 exp Cyanoacrylates/ 4934 31 "tissue adhesive*".ti,ab. 1886 32 Cyanoacrylate*.ti,ab. 4419 33 Enbucrilate.ti,ab. 35 34 VenaSeal.ti,ab. 9 35 VariClose.ti,ab. 6 36 VeClose.ti,ab. 3 37 Histoacryl.ti,ab. 513 38 or/30‐37 7716 39 MOCA.ti,ab. 1488 40 ClariVein.ti,ab. 32 41 or/39‐40 1510 42 "Endovenous steam".ti,ab. 9 43 steam.ti,ab. 7174 44 or/42‐43 7174 45 11 and 29 8205 46 11 and 38 850 47 11 and 41 42 48 11 and 44 235 49 29 and 38 540 50 29 and 41 58 51 29 and 44 153 52 38 and 41 2 53 38 and 44 1 54 41 and 44 6 55 or/45‐54 9670 56 4 and 55 1693 57 randomized controlled trial.pt. 516039 58 controlled clinical trial.pt. 101743 59 randomized.ab. 453171 60 placebo.ab. 210619 61 drug therapy.fs. 2199170 62 randomly.ab. 312199 63 trial.ab. 477783 64 groups.ab. 1925728 65 or/57‐64 4548008 66 56 and 65 427	9 Jan 2018: 25
EMBASE 2017 and 2018 only	1 exp Varicose Veins/ 30954 2 exp Venous Insufficiency/ 6648 3 (varic* or incomp* or insuffici* or tortuous or sapheno* or GSV or CVI).ti,ab. 404745 4 or/1‐3 418741 5 exp Laser Therapy/ 18166 6 exp Catheter Ablation/ 27123 7 (endovenous or EVLA or EVLT or radiofrequency or laser* or ablation* or obliteration* or RFA).ti,ab. 305281 8 NBCA.ti,ab. 777 9 "Mechanochemical endovenous Ablation".ti,ab. 24 10 "Mechanochemical Ablation".ti,ab. 40 11 or/5‐10 315178 12 exp Sclerotherapy/ 8990 13 exp Sclerosing Solutions/ 7375 14 sclero*.ti,ab. 185006 15 (tetradecyl adj2 (sulfate or sulphate)).ti,ab. 410 16 exp Sodium Tetradecyl Sulfate/ 1078 17 exp Saline Solution, Hypertonic/ 137265 18 Ethanolamines/ 1670 19 (polydocanol or polidocanol).ti,ab. 760 20 saline.ti,ab. 160073 21 (ethanolamine adj2 oleate).ti,ab. 299 22 (sodium adj2 morrhuate).ti,ab. 97 23 sotradecol.ti,ab. 57 24 (aetoxisclerol or aethoxysclerol).ti,ab. 42 25 (aetoxiskerol or aethoxyskerol).ti,ab. 1 26 Turbofoam.ti,ab. 3 27 (foam* or microfoam*).ti,ab. 22781 28 varisolve.ti,ab. 5 29 or/12‐28 432105 30 exp Cyanoacrylates/ 1015 31 "tissue adhesive*".ti,ab. 1263 32 Cyanoacrylate*.ti,ab. 4139 33 Enbucrilate.ti,ab. 27 34 VenaSeal.ti,ab. 26 35 VariClose.ti,ab. 11 36 VeClose.ti,ab. 5 37 Histoacryl.ti,ab. 519 38 or/30‐37 5714 39 MOCA.ti,ab. 3454 40 ClariVein.ti,ab. 40 41 or/39‐40 3483 42 "Endovenous steam".ti,ab. 12 43 steam.ti,ab. 7068 44 or/42‐43 7068 45 11 and 29 10224 46 11 and 38 1029 47 11 and 41 70 48 11 and 44 367 49 29 and 38 666 50 29 and 41 126 51 29 and 44 224 52 38 and 41 10 53 38 and 44 6 54 41 and 44 10 55 or/45‐54 12009 56 4 and 55 2299 57 randomized controlled trial/ 434283 58 controlled clinical trial/ 407173 59 random$.ti,ab. 1117832 60 randomization/ 68256 61 intermethod comparison/ 218276 62 placebo.ti,ab. 213565 63 (compare or compared or comparison).ti. 322736 64 ((evaluated or evaluate or evaluating or assessed or assess) and (compare or compared or comparing or comparison)).ab. 1540369 65 (open adj label).ti,ab. 59678 66 ((double or single or doubly or singly) adj (blind or blinded or blindly)).ti,ab. 152435 67 double blind procedure/ 118292 68 parallel group$1.ti,ab. 18718 69 (crossover or cross over).ti,ab. 69418 70 ((assign$ or match or matched or allocation) adj5 (alternate or group$1 or intervention$1 or patient$1 or subject$1 or participant$1)).ti,ab. 238152 71 (controlled adj7 (study or design or trial)).ti,ab. 249992 72 (volunteer or volunteers).ti,ab. 166514 73 trial.ti. 203926 74 or/57‐73 3255961 75 56 and 74 561	9 Jan 2018: 65
AMED 2017 and 2018 only	1 exp Varicose Veins/ 64 2 exp Venous Insufficiency/ 50 3 (varic* or incomp* or insuffici* or tortuous or sapheno* or GSV or CVI).ti,ab. 2794 4 or/1‐3 2855 5 exp Laser Therapy/ 169 6 exp Catheter Ablation/ 0 7 (endovenous or EVLA or EVLT or radiofrequency or laser* or ablation* or obliteration* or RFA).ti,ab. 1122 8 NBCA.ti,ab. 0 9 "Mechanochemical endovenous Ablation".ti,ab. 0 10 "Mechanochemical Ablation".ti,ab. 0 11 or/5‐10 1133 12 exp Sclerotherapy/ 0 13 exp Sclerosing Solutions/ 0 14 sclero*.ti,ab. 2225 15 (tetradecyl adj2 (sulfate or sulphate)).ti,ab. 0 16 exp Sodium Tetradecyl Sulfate/ 0 17 exp Saline Solution, Hypertonic/ 0 18 Ethanolamines/ 0 19 (polydocanol or polidocanol).ti,ab. 3 20 saline.ti,ab. 532 21 (ethanolamine adj2 oleate).ti,ab. 0 22 (sodium adj2 morrhuate).ti,ab. 1 23 sotradecol.ti,ab. 0 24 (aetoxisclerol or aethoxysclerol).ti,ab. 0 25 (aetoxiskerol or aethoxyskerol).ti,ab. 0 26 Turbofoam.ti,ab. 0 27 (foam* or microfoam*).ti,ab. 270 28 varisolve.ti,ab. 0 29 or/12‐28 3024 30 exp Cyanoacrylates/ 0 31 "tissue adhesive*".ti,ab. 2 32 Cyanoacrylate*.ti,ab. 3 33 Enbucrilate.ti,ab. 1 34 VenaSeal.ti,ab. 0 35 VariClose.ti,ab. 0 36 VeClose.ti,ab. 0 37 Histoacryl.ti,ab. 2 38 or/30‐37 7 39 MOCA.ti,ab. 6 40 ClariVein.ti,ab. 0 41 or/39‐40 6 42 "Endovenous steam".ti,ab. 0 43 steam.ti,ab. 73 44 or/42‐43 73 45 11 and 29 14 46 11 and 38 0 47 11 and 41 0 48 11 and 44 1 49 29 and 38 0 50 29 and 41 0 51 29 and 44 0 52 38 and 41 0 53 38 and 44 0 54 41 and 44 0 55 or/45‐54 15 56 4 and 55 2	9 Jan 2018: 0
CINAHL 2017 and 2018 only	S62 S4 AND S54 AND S61 78 S61 S55 OR S56 OR S57 OR S58 OR S59 OR S60 958,825 S60 TX randomly 42,126 S59 TX "treatment as usual" 724 S58 TX "double‐blind*" 760,703 S57 TX "single‐blind*" 8,730 S56 TX trial 238,589 S55 MH "Clinical Trials" 91,184 S54 S45 OR S46 OR S47 OR S48 OR S49 OR S50 OR S51 OR S52 OR S53 840 S53 S38 AND S44 0 S52 S38 AND S41 0 S51 S29 AND S44 22 S50 S29 AND S41 9 S49 S29 AND S38 45 S48 S11 AND S44 40 S47 S11 AND S41 5 S46 S11 AND S38 51 S45 S11 AND S29 696 S44 S42 OR S43 749 S43 TX steam 749 S42 TX "Endovenous steam" 0 S41 S39 OR S40 482 S40 TX ClariVein 2 S39 TX MOCA 482 S38 S30 OR S31 OR S32 OR S33 OR S34 OR S35 OR S36 OR S37 822 S37 TX Histoacryl 25 S36 TX VeClose 0 S35 TX VariClose 0 S34 TX VenaSeal 0 S33 TX Enbucrilate 2 S32 TX Cyanoacrylate* 270 S31 TX "tissue adhesive*" 610 S30 TX Cyanoacrylates 270 S29 S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 OR S22 OR S23 OR S24 OR S25 OR S26 OR S27 OR S28 38,921 S28 TX varisolve 0 S27 TX foam* or microfoam* 2,605 S26 TX Turbofoam 0 S25 TX aetoxiskerol or aethoxyskerol 0 S24 TX aetoxisclerol or aethoxysclerol 0 S23 TX sotradecol 2 S22 TX sodium N2 morrhuate 12 S21 TX ethanolamine N2 oleate 13 S20 TX saline 8,727 S19 TX polydocanol or polidocanol 33 S18 (MH "Ethanolamines+") 6,503 S17 (MH "Saline Solution, Hypertonic") 533 S16 TX Sodium Tetradecyl Sulfate 6 S15 TX (tetradecyl N2 (sulfate or sulphate)) 10 S14 TX sclero* 21,475 S13 (MH "Sclerosing Solutions") 182 S12 (MH "Sclerotherapy") 365 S11 S5 OR S6 OR S7 OR S8 OR S9 OR S10 24,433 S10 TX "Mechanochemical Ablation" 3 S9 TX "Mechanochemical endovenous Ablation" 1 S8 TX NBCA 22 S7 TX endovenous or EVLA or EVLT or radiofrequency or laser* or ablation* or obliteration* or RFA 24,345 S6 (MH "Catheter Ablation") 6,674 S5 (MH "Laser Therapy+") 5,572 S4 (S1 OR S2 OR S3) 46,802 S3 TX varic* or incomp* or insuffici* or tortuous or sapheno* or GSV or CVI 45,221 S2 (MH "Venous Insufficiency+") 686 S1 (MH "Varicose Veins+") 2,378	9 Jan 2018: 1