Jain 2016.

Study characteristics
Methods	Randomised controlled trial
Participants	Preterm infants (birth weight 1000 to 1249 grams and gestational age > 30 weeks at birth) who have antenatal evidence of absent end‐diastolic flow velocities (presumed in umbilical artery) Setting: Department of Paediatrics, Postgraduate Institute of Medical Education & Research, Chandigarh, India (2013 to 2014)
Interventions	Feed advancement at 20 mL/kg/d (n = 15) vs 30 mL/kg/d (n = 15)
Outcomes	NEC Late‐onset bloodstream (culture‐positive) infection In‐hospital mortality Time to achieve full enteral feeds
Notes	Prespecified subgroup of a larger trial that enrolled infants with birth weight > 1250 grams and compared feed advancement at 30 mL/kg/d vs 40 mL/kg/d Additional data courtesy of Dr Mukhopadhyay (September 2014)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated
Allocation concealment (selection bias)	Low risk	Sealed, opaque envelopes
Blinding of participants and personnel (performance bias) All outcomes	High risk	Unmasked
Blinding of outcome assessment (detection bias) All outcomes	High risk	Unmasked
Incomplete outcome data (attrition bias) All outcomes	Low risk	Complete follow‐up for primary outcomes
Selective reporting (reporting bias)	Low risk	Unlikely
Other bias	Low risk	No evidence of baseline imbalance