Krishnamurthy 2010.

Study characteristics
Methods	Randomised controlled trial
Participants	Preterm infants (birth weight 1000 to 1499 grams) and gestational age < 34 weeks at birth Exclusion criteria included respiratory distress, mechanical ventilation, inotrope support, and umbilical arterial or venous catheterisation. Setting: Department of Paediatrics, University College of Medical Sciences, Delhi, India (2007 to 2009)
Interventions	Feed advancement at 20 mL/kg/d (n = 50) vs 30 mL/kg/d (n = 50)
Outcomes	NEC Incidence of invasive infection In‐hospital mortality Time to regain birth weight Time to achieve full enteral feeds Time to hospital discharge
Notes	All feeds were delivered by gavage via nasogastric tube at 2‐hour intervals. Feeds were ceased if any of the following occurred: residual gastric contents > 50% of previous feed volume (delayed if volume was 25% to 50%), > 3 episodes of apnoea in the preceding hour, abdominal distension or tenderness, or bloody stools (including occult blood). Parenteral nutrition was not available.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated sequence
Allocation concealment (selection bias)	Low risk	Opaque, sealed envelopes
Blinding of participants and personnel (performance bias) All outcomes	High risk	Unmasked
Blinding of outcome assessment (detection bias) All outcomes	High risk	Unmasked
Incomplete outcome data (attrition bias) All outcomes	Low risk	No loss to follow‐up
Selective reporting (reporting bias)	Low risk	Unlikely
Other bias	Low risk	No evidence of baseline imbalance