Modi 2015.

Study characteristics
Methods	Randomised controlled trial
Participants	Newborn infants with birth weight of 750 to 1250 grams who commenced enteral feeds within 4 days after birth. Mean gestational age of participants was 31 weeks. Exclusion criteria were (quote: "gross congenital malformation and anomalies of gastrointestinal tract"). Setting: Department of Neonatology, Maulana Azad Medical College, New Delhi, India (2012 to 2014)
Interventions	Feed advancement at 15 to 20 mL/kg/d (n = 65) vs 30 to 40 mL/kg/d (n = 66)
Outcomes	NEC Incidence of feed intolerance Invasive infection In‐hospital (all‐cause) mortality Mean daily weight gain Time to achieve full enteral feeds
Notes	Published as abstract only Further information available from www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=5289
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Stratified block randomisation (computer‐generated)
Allocation concealment (selection bias)	Low risk	Sequentially numbered, sealed, opaque envelopes
Blinding of participants and personnel (performance bias) All outcomes	High risk	Unmasked
Blinding of outcome assessment (detection bias) All outcomes	High risk	Unmasked
Incomplete outcome data (attrition bias) All outcomes	Low risk	No loss to follow‐up
Selective reporting (reporting bias)	Low risk	Unlikely
Other bias	Low risk	No evidence of baseline imbalance