Raban 2014b.

Study characteristics
Methods	Randomised controlled trial (2 × 2 factorial design with Raban 2014a)
Participants	ELBW infants Setting: Groote Schuur Hospital, Cape Town, South Africa (2011 to 2013)
Interventions	Feed advancement (from 24 mL/kg/d on day 1) in daily increments of 24 mL/kg (n = 52) vs 36 mL/kg (n = 50) until enteral feeds of 200 mL/kg/d were attained
Outcomes	NEC Feed intolerance Mortality Invasive infection Time to attain 1500 grams of weight Time to regain birth weight
Notes	Factorial design also randomised to commencing feeds on day 1 (24 mL/kg) or day 2 (12 mL/kg). Infants received maternal‐expressed breast milk or donor breast milk. Trial registration: ISRCTN96923718
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	High risk	Unmasked
Blinding of outcome assessment (detection bias) All outcomes	High risk	Unmasked
Incomplete outcome data (attrition bias) All outcomes	Low risk	Complete follow‐up for primary outcomes
Selective reporting (reporting bias)	Low risk	Unlikely
Other bias	Low risk	No evidence of baseline imbalance