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. 2021 Aug 24;2021(8):CD001241. doi: 10.1002/14651858.CD001241.pub8

Saha 2019.

Study characteristics
Methods Randomised controlled trial
Participants Preterm infants of birth weight 1200 to 1500 grams (appropriate for gestational age)
Exclusion criteria included recurrent apnoea, respiratory distress requiring supplemental oxygen, and receipt of inotrope support.
Setting: Neonatal Unit, Dhaka Shishu Hospital, Dhaka, Bangladesh (2017 to 2018)
Interventions Feed (expressed human milk only) advancement at 20 mL/kg/d (n = 55) vs 30 mL/kg/d (n = 38)
Outcomes
  • NEC

  • Mortality pre‐discharge

  • Feed intolerance (interruption)

  • Duration of hospital stay

Notes Further information sought from Dr Saha and colleagues.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Not stated
Allocation concealment (selection bias) Low risk Opaque, sealed envelopes
Blinding of participants and personnel (performance bias)
All outcomes High risk Unmasked
Blinding of outcome assessment (detection bias)
All outcomes High risk Unmasked
Incomplete outcome data (attrition bias)
All outcomes Low risk Complete until hospital discharge
Selective reporting (reporting bias) Unclear risk Invasive infection not reported.
Other bias Unclear risk No evidence of baseline imbalance