SIFT 2016.

Study characteristics
Methods	Randomised controlled trial
Participants	Very preterm or VLBW infants
Interventions	Feeds advancement at 18 mL/kg/d (n = 1404) vs 30 mL/kg/d (n = 1400) (June 2013 to June 2015)
Outcomes	NEC Mortality Neurodisability at 24 months post‐term Invasive infection Time to full milk feeds Growth (change in z‐score ‐ weight and head circumference for gestational age) from birth to discharge home Length of time in intensive care Length of hospital stay
Notes	See: Declarations of interest
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated
Allocation concealment (selection bias)	Low risk	Computer‐based random allocation
Blinding of participants and personnel (performance bias) All outcomes	High risk	Unmasked
Blinding of outcome assessment (detection bias) All outcomes	High risk	Unmasked (radiologists may have been masked)
Incomplete outcome data (attrition bias) All outcomes	Low risk	> 99% outcome data for in‐hospital outcomes > 87% outcome data for neurodevelopmental outcomes at 18 to 24 months
Selective reporting (reporting bias)	Low risk	Adhered to protocol
Other bias	Low risk	No evidence of baseline imbalance

ELBW: extremely low birth weight; n: number of infants; NEC: necrotising enterocolitis; VLBW: very low birth weight