Comparison 1. Comparison between two prophylaxis regimens.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Joint bleeds per year	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.2 Joint bleeds per year (2)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.3 Spontaneous joint bleeds	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.4 Joint bleeds per year (3)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.5 Total bleeds per year	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.6 Overall bleeding frequency (bleeds per 100 days)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.7 Annualised bleeding rates	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.8 Total bleeding frequency (HB)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.9 Overall bleeding frequency	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.10 Total bleeds per year (2)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.11 Total treatment emergent adverse event	1		Risk Ratio (IV, Fixed, 95% CI)	Totals not selected
1.12 Rate of adverse events	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected