Comparison 3. Prophylaxis versus on‐demand.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 Mean total joint bleeds per year	2	164	Mean Difference (IV, Random, 95% CI)	‐30.34 [‐46.95, ‐13.73]
3.2 Mean change in joint health scores (CAJAS)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.3 Mean total bleeds per year	2	164	Mean Difference (IV, Random, 95% CI)	‐40.24 [‐64.04, ‐16.44]
3.4 Pain scores	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.5 Radiologic measurements of joint damage (deterioration shown in eMRI)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.6 Participants with adverse events	2	131	Risk Ratio (IV, Fixed, 95% CI)	1.71 [1.24, 2.37]