Date	Event	Description
12 August 2021	New citation required and conclusions have changed	This review of previously treated individuals is one of two set to replace the original 2011 published review ‐ Clotting factor concentrates given to prevent bleeding and bleeding‐related complications in people with hemophilia A or B (Iorio 2011). The original review is currently still available on the Cochrane Library, but when this is next updated (currently in production), will only include previously untreated individuals. The conclusions of this new review have changed from the original review. Previously we identified evidence that the use of these concentrates was effective in decreasing the frequency of joint bleeds and in partially preventing or slowing down the development of arthropathy. Currently, in relation to people previously treated with clotting factor concentrates, we have found evidence that the use of these concentrates may be effective in decreasing the frequency of total bleeds and joint bleeds and improve joint function, pain and quality of life, even though this does not translate into a detectable improvement of articular damage when assessed by radiologic assessment.
12 August 2021	New search has been performed	The review 'Clotting factor concentrates given to prevent bleeding and bleeding‐related complications in people with hemophilia A or B' has been split into two reviews, of which this is the first to be published. The second review is in production: Clotting factor concentrates for preventing bleeding and bleeding‐related complications in previously untreated individuals with haemophilia A or B. The previous review (which included both people previously and not previously treated for bleeding and related complications) included six studies, of which three were regarded as not eligible for this review (Carlsson 1997; ESPRIT 2011; Manco‐Johnson 2007). 10 trials (32 references) are included in this review (A‐LONG 2014; Aronstam 1976; Aronstam 1977; LEOPOLD II 2015; LipLong 2012; Morfini 1976; PROPEL III 2020; SPINART 2013; Valentino 2012; Valentino 2014).  The number of participants included in the review has increased from 142 to 608.