Skip to main content
. 1999 Oct 25;1999(4):CD001805. doi: 10.1002/14651858.CD001805

USA 1980.

Methods 'Randomly assigned by blind draw' into three groups, no further information. Three women delivered and one withdrew before treatment.
Participants 36 primiparous women with pre‐eclampsia, defined as hypertension plus proteinuria and/or oedema. Age 15‐33, gestation 28‐40 weeks. Excluded if cardiac disease, renal or pulmonary insufficiency, severe pre‐eclampsia (if required antihypertensive drugs and prompt delivery).
Interventions Expansion: (a) plasmanate 500 ml over eight hours day one, 250 ml over four hours day two (b) dextran 40 1000 ml over eight hours day one, 500 ml over four hours day two. 
 Control: 5% dextrose in distilled water 1000 ml over eight hours day one, 500ml over four hours day two. 
 Treatment started after 24 hours assessment, with bed rest, sedatives and magnesium sulphate as indicated.
Outcomes Women: use of magnesium sulphate, caesarean section, preterm delivery, placental abruption, change in urine output and haematocrit. 
 Baby: death.
Notes Twins mentioned in the text, but not clear how many and in which group.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear

BP=blood pressure; DBP=diastolic blood pressure; mg=milligram; ml=millilitre; mmHg=millimeter of mercury; PIH=pregnancy induced hypertension; SBP=systolic blood pressure