USA 1980.
Methods | 'Randomly assigned by blind draw' into three groups, no further information. Three women delivered and one withdrew before treatment. | |
Participants | 36 primiparous women with pre‐eclampsia, defined as hypertension plus proteinuria and/or oedema. Age 15‐33, gestation 28‐40 weeks. Excluded if cardiac disease, renal or pulmonary insufficiency, severe pre‐eclampsia (if required antihypertensive drugs and prompt delivery). | |
Interventions | Expansion: (a) plasmanate 500 ml over eight hours day one, 250 ml over four hours day two (b) dextran 40 1000 ml over eight hours day one, 500 ml over four hours day two. Control: 5% dextrose in distilled water 1000 ml over eight hours day one, 500ml over four hours day two. Treatment started after 24 hours assessment, with bed rest, sedatives and magnesium sulphate as indicated. | |
Outcomes | Women: use of magnesium sulphate, caesarean section, preterm delivery, placental abruption, change in urine output and haematocrit. Baby: death. | |
Notes | Twins mentioned in the text, but not clear how many and in which group. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Unclear risk | B ‐ Unclear |
BP=blood pressure; DBP=diastolic blood pressure; mg=milligram; ml=millilitre; mmHg=millimeter of mercury; PIH=pregnancy induced hypertension; SBP=systolic blood pressure