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. 2021 Aug 31;18(8):e1003728. doi: 10.1371/journal.pmed.1003728

Table 2. Sm—Symptoms-only model.

Covariate Coefficient (95% CI) Odds Ratio (95% CI) p-value
Demographics
Age-group (ref = 60–69 years) 18–39 −3.85 (−4.75–2.96) 0.02 (0.01–0.05) <0.001
40–49 −1.93 (−2.40–1.46) 0.14 (0.09–0.23) <0.001
50–59 −1.11 (−1.43–0.78) 0.33 (0.24–0.46) <0.001
70–79 0.63 (0.43–0.82) 1.87 (1.53–2.28) <0.001
80+ 0.72 (0.52–0.93) 2.06 (1.69–2.52) <0.001
Sex (ref = female) male 0.77 (0.63–0.91) 2.16 (1.87–2.48) <0.001
Risk factors
Smoking status (ref = non-smoker) current 0.61 (0.37–0.84) 1.84 (1.45–2.32) <0.001
ex-smoker 0.21 (−0.02–0.43) 1.23 (0.98–1.54) 0.068
Symptoms
Abdominal pain Yes 0.77 (0.56–0.98) 2.17 (1.76–2.67) <0.001
Appetite loss Yes 0.61 (0.33–0.89) 1.84 (1.39–2.43) <0.001
Dyspepsia Yes 0.46 (0.16–0.75) 1.58 (1.18–2.12) <0.001
Sign
Abdominal mass Yes 1.09 (0.59–1.59) 2.98 (1.81–4.93) <0.001
Chest signs Yes 1.32 (0.60–2.04) 3.73 (1.81–7.68) <0.001
Iron deficiency anaemia Yes 1.15 (0.82–1.48) 3.16 (2.27–4.41) <0.001
Jaundice Yes 1.89 (1.33–2.45) 6.62 (3.77–11.6) <0.001
Lymphadenopathy Yes 1.54 (0.73–2.35) 4.67 (2.08–10.5) <0.001
Venous thromboembolism Yes 1.10 (0.47–1.73) 3.00 (1.60–5.64) <0.001
Constant −4.97 (−5.2–4.75) <0.001

Candidate covariates included in the backwards stepwise selection procedure using p < 0.01 to retain covariates included the following: sex, age-group, smoking status, abdominal mass, abdominal pain, appetite loss, back pain, chest pain (noncardiac), chest signs, change in bowel habit, dyspepsia, dysphagia, iron deficiency anaemia, jaundice, lymphadenopathy, and venous thromboembolism.