Table 2. Proteins obtained from orthogonal partial least squares-discriminant analysis when comparing additive manufacturing operators Monday vs Friday year1.
| Protein Name | Gene | UniProt Accession | Monday LFQ Intensity | Friday LFQ Intensity | Fold change Friday/Monday # | Protein Function (from UniProt) |
|---|---|---|---|---|---|---|
| Fibrinogen beta chain | FGB | P02675 | 1.3E+7 (1.2E+7–3.5E+7) | 3.4E+7 (1.9E+7–4.4E+7) | 2.6 (+) | Adaptive immunity, Blood coagulation, Innate immunity |
| Golgi membrane protein 1 | GOLM1 | Q8NBJ4 | 3.0E+6 (2.2E+6–5.8E+6) | 4.9E+6 (2.5E+6–6.2E+6) * | 1.6 (+) | Cellular protein metabolic process, Regulation of lipid metabolic process |
| Immunoglobulin heavy variable 1–69 | IGHV1-69 | P01742 | 2.1E+6 (1.5E+6–3.7E+6) | 1.6E+6 (9.6E+5–2.9E+6) | 0.8 (-) | B cell receptor signaling pathway, Complement activation, Innate immune response |
| Immunoglobulin J chain | JCHAIN | P01591 | 1.7E+8 (1.2E+8–2.8E+8) | 9.7E+7 (6.6E+7–1.1E+8) * | 0.6 (-) | Adaptive and innate immune response |
| Immunoglobulin kappa constant | IGKC | P01834 | 4.6E+7 (3.5E+7–6.1E+7) | 3.3E+7 (1.5E+7–4.1E+7) | 0.7 (-) | B cell receptor signaling pathway, Complement activation, Innate immune response |
| Immunoglobulin kappa variable 3–11 | IGKV3D-11 | P04433 | 2.5E+6 (1.4E+6–3.7E+6) | 1.4E+6 (8.6E+5–2.7E+6) | 0.6 (-) | Complement activation, Immune response |
| Lactoperoxidase | LPO | P22079 | 5.5E+6 (4.5E+6–9.8E+6) | 5.9E+6 (5.6E+6–1.1E+7) | 1.1 (+) | Hydrogen peroxide catabolic process, Response to oxidative stress |
| Prolactin-inducible protein | PIP | P12273 | 4.4E+8 (1.6E+8–7.1E+8) | 2.2E+8 (1.6E+8–4.4E+8) | 0.5 (-) | Negative regulation of T cell apoptotic process, Regulation of immune system process |
| Protein S100-A6 | S100A6 | P06703 | 1.7E+6 (1.2E+6–2.1E+6) | 3.6E+6 (1.8E+6–6.4E+6) * | 2.1 (+) | Positive regulation of fibroblast proliferation, Signal transduction |
| Uteroglobin | SCGB1A1 | P11684 | 1.3E+7 (8.7E+6–3.1E+7) | 2.3E+7 (1.9E+7–4.7E+7) * | 1.8 (+) | Regulation of inflammatory response, signal transduction |
| WAP four-disulfide core domain protein 2 | WFDC2 | Q14508 | 4.7E+7 (3.5E+7–8.5E+7) | 2.9E+7 (2.4E+7–5.6E+7) * | 0.6 (-) | Proteolysis |
| Vitronectin | VTN | P04004 | 1.9E+5 (7.3E+4–3.6E+5) | 4.9E+5 (3.0E+5–6.0E+5) | 2.6 (+) | Immune response. Cell adhesion, Regulation of Complement activation |
Values are median (range), LFQ–label free quantification. # Sign in parenthesis depicts increase (+) or decrease (-) over the workweek.
* p<0.05 Wilcoxon matched pairs test when comparing Monday vs Friday samples.