. Author manuscript; available in PMC: 2021 Aug 31.

Published in final edited form as: Am J Med Genet A. 2019 Apr 3;179(6):983–992. doi: 10.1002/ajmg.a.61140

TABLE 5.

Changes in ABC-C scores over time based on genotype

Genotype slope estimate^b (95% CI)	Irritability^d	Lethargy^c	Stereotypy^c	Hyperactivity^e
Deletion	0.41 (0.27, 0.56)^a	0.16 (0.07, 0.26)^a	0.05 (−0.02, 0.11)	0.67 (0.43, 0.90)^a
UBE3A mutation	1.45 (1.06, 1.83)^a	0.40 (0.14, 0.66)^a	0.31 (0.10, 0.52)^a	1.18 (0.54, 1.81)^a
UPD /ImpD	0.76 (0.45, 1.07)^a	−0.07 (−0.28, 0.15)	−0.03 (−0.19, 0.13)	0.59 (0.07, 1.10)^a

Abbreviations: ABC-C, Aberrant Behavior Checklist-Community; UPD, paternal uniparental disomy for chromosome 15q11q13; ImpD, imprinting defects that alter expression of the maternally inherited copy of UBE3A.

Change in ABC-C subscale score found to be significant over time.

Slope estimate indicates average change in score per year.

Fixed effect p-value <.05 for age, genotype, and age*genotype interaction.

Fixed effect p-value <.05 for age and age*genotype interaction only.

Fixed effect p-value <.05 for age only.