TABLE 6.
Rate of change in odds of parental report of maladaptive behavior over time by genotype
| Behavior | Deletion (N = 211) | UPD/ImpD (N = 56) | UBE3A (N = 33) |
|---|---|---|---|
| Factor by which odds of behavior changes with 1 year increase in age (95% CI)a,b | |||
| Mouthing behaviors | 0.85 (0.76, 0.96)c | ||
| Easy excitability | |||
| Males | 1.30 (1.00, 1.69) | ||
| Females | 1.07 (0.81, 1.41) | ||
| Short attention span | |||
| Males | 1.17 (0.94, 1.46) | ||
| Females | 0.96 (0.81, 1.13) | ||
| Fascination with water | 2.51 (1.60, 3.94)c | 1.65 (1.05, 2.61)c | 1.18 (0.76, 1.84) |
| Hand flapping | 1.25 (1.11, 1.41)c | ||
| Hyperactive | 0.94 (0.89, 1.00) | ||
| Frequent laughter | 1.30 (1.10, 1.53)c | 0.86 (0.68, 1.10) | 0.84 (0.63, 1.12) |
| Aggressive behavior (overall) | 1.30 (1.13, 1.48)c | ||
| Biting | 0.93 (0.86, 0.99)c | ||
| Pinching | 1.15 (1.04, 1.27)c | ||
| Hair pulling | 1.01 (0.95, 1.07) | 0.84 (0.73, 0.97)c | 1.10 (0.91, 1.33) |
| Anxiety | 1.14 (1.04, 1.24)c | ||
| Temper tantrums | 1.08 (0.98, 1.18) | ||
Abbreviations: UPD, paternal uniparental disomy for chromosome 15q11q13; ImpD, imprinting defects that alter expression of the maternally inherited copy of UBE3A.
A value greater than 1 indicates an increase in odds of exhibiting behavior over time, while a value less than 1 indicates a decrease in odds over time. A confidence interval that includes 1.0 indicates that the change in odds over time is not significant.
For behaviors where there is only one value across the different genotypes, the rate of change does not differ based on genotype, hence results are for all genotypes combined.
Log odds of displaying behavior found to change significantly over time.