FIG 4.

Low-grade tumors detected in patients with constitutional mismatch repair deficiency undergoing surveillance. (A) Distribution of low-grade tumors in the full study cohort (n = 64). (B) Percentage of polyps with high-grade dysplasia and the frequency of preventative surgery. (C) Magnetic resonance imaging scans showing tumor transformation and time to transformation of six nonresected low-grade gliomas. (D) Cumulative likelihood of high-grade transformation over time for brain (red) and GI (blue) tumors.