TABLE 2.
Individual pharmacokinetics of DIM, 2-ox-DIM, plus pyrano-DIM (3-methylenehydroxy-DIM): Noncompartmental model
| Volunteer | Tmax DIM | Tmax OH-DIMa | Cmax DIM | Cmax OH-DIMb | AUC0-48hr DIM | AUC0-48hr OH-DIM | t1/2 DIM | t1/2 OH-DIMa | Cl DIMa | Vdis DIMa |
|---|---|---|---|---|---|---|---|---|---|---|
| h | h | pmol/ml | pmol/ml | pmol x h x ml−1 | pmol x h x ml−1b | h | h | L/h | L | |
| BaP021 | — | 0.25 | — | 4230 | — | 11,100 | — | 9.84 | — | — |
| BaP022 | 4.0 | 8 | 265 | 205 | 2890 | 2740 | 4.13 | 8.36 | 127 | 759 |
| BaP025 | 1.5 | 1.5 | 1770 | 8280 | 4190 | 16,600 | 3.87 | 5.12 | 87.7 | 490 |
| BaP028 | 3.0 | 3.0 | 362 | 290 | 2990 | 4510 | 3.76 | 14.1 | 123 | 669 |
| BaP031 | 3.0 | 3.0 | 380 | 184 | 5020 | 2910 | 8.85 | 11.9 | 73.3 | 937 |
| BaP041 | 1.5 | 2.0 | 68 | 125 | 72 | 1500 | 1.22 | 6.14 | — | — |
| BaP042 | 3.0 | 3.0 | 120 | 80 | 935 | 699 | 3.92 | 9.93 | 393 | 2220 |
| 2.67 ± 0.98 | 2.96 ± 2.44 | 423 ± 610 | 1910 ± 3190 | 2300 ± 2000 | 5730 ± 5900 | 4.29 ± 2.48 | 9.34 ± 3.13 | 161 ± 132 | 1010 ± 693 |
a The reported Tmax is for pyrano-DIM.
b The reported Cmax and AUC0-48hr are for the sum of 2-ox-DIM and pyrano-DIM.