Table 3.
Cox Proportional Hazard Analysis for Associations Between Serum NGAL Levels and CV Mortality During the Follow-Up of 10 Years in Patients with CHD by Sensitivity Analysis, Using “CVD History” as a Covariate
| Variables | Univariate Cox | Multivariate Cox | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P Value | HR | 95% CI | P Value | |
| Age (per 1-SD increase) | 1.64 | 1.24–2.63 | 0.024 | 1.42 | 1.13–1.98 | 0.125 |
| Sex | 1.35 | 0.96–1.72 | 0.258 | |||
| BMI (per 1-SD increase) | 1.84 | 1.24–2.59 | 0.015 | 1.72 | 1.13–2.15 | 0.027 |
| Smoker | 1.61 | 1.10–1.95 | 0.019 | 1.43 | 1.08–1.89 | 0.039 |
| Drinker | 1.76 | 1.11–2.03 | 0.017 | 1.32 | 0.93–1.85 | 0.071 |
| CVD history on admission | 2.73 | 1.52–4.99 | <0.001 | 2.30 | 1.39–4.56 | 0.009 |
| Preserved LVEF | 1.75 | 1.43–2.76 | 0.039 | 1.25 | 0.89–1.75 | 0.113 |
| Diabetes mellitus | 2.2 | 1.4–3.4 | 0.005 | 1.9 | 1.1–2.6 | 0.010 |
| Systolic BP (per 1-SD increase) | 1.50 | 0.87–1.71 | 0.110 | 1.21 | 0.73–1.56 | 0.215 |
| Diastolic BP (per 1-SD increase) | 1.19 | 0.64–1.50 | 0.271 | |||
| Laboratory measurements | ||||||
| SCr (per 1-SD increase) | 1.91 | 1.14–3.70 | 0.014 | 1.72 | 1.08–2.69 | 0.043 |
| BUN (per 1-SD increase) | 1.36 | 0.89–1.67 | 0.263 | |||
| hs-CRP (per 1-SD increase) | 1.51 | 1.09–2.40 | 0.042 | 1.22 | 0.95–1.72 | 0.102 |
| Hb (per 1-SD increase) | 1.21 | 0.90–1.53 | 0.215 | |||
| ALB (per 1-SD increase) | 0.74 | 0.24–0.93 | 0.031 | 0.82 | 0.41–1.35 | 0.076 |
| TG (per 1-SD increase) | 2.10 | 1.33–3.82 | 0.010 | 1.95 | 1.27–3.48 | 0.019 |
| LDL (per 1-SD increase) | 2.27 | 1.44–5.28 | <0.001 | 2.09 | 1.36–4.53 | 0.011 |
| TC (per 1-SD increase) | 2.21 | 1.63–4.11 | 0.009 | 1.98 | 1.50–4.01 | 0.013 |
| FBG (per 1-SD increase) | 1.38 | 0.89–2.00 | 0.154 | |||
| NGAL (per 1-SD increase) | 2.74 | 1.75–5.37 | <0.001 | 2.62 | 1.51–4.96 | <0.001 |
Notes: Adjusted for age, gender, BMI, smoker, drinker, diabetes mellitus, BP, preserved LVEF and laboratory measurements (FBG, TC, TG, LDL, Hb, ALB, hs-CRP, SCr and BUN).
Abbreviations: NGAL, neutrophil gelatinase-associated lipocalin; CV, cardiovascular; CHD, coronary heart disease; CVD, cardiovascular disease; HR, hazard ratio; CI, confidence interval; BMI, body mass index; LVEF, left ventricular ejection fraction; BP, blood pressure; SCr, serum creatinine; BUN, serum urea nitrogen; hs-CRP, high-sensitivity C-reactive protein; Hb, hemoglobin; ALB, albumin; TG, triglycerides; LDL, low-density lipoprotein cholesterol; TC, total cholesterol; FBG, fasting blood glucose.