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. 2021 Sep 1;12(6):1389–1408. doi: 10.14336/AD.2021.0406

Figure 1.

Figure 1.

Amyloidopathy in the brain regions of morphine-dependent macaques. Representative western blots showing the expression of APP, Aβ mOC64, pro-IL1-β and mature- IL1-β in (A) frontal cortex (FC) and (B) basal ganglia (BG) of saline and morphine dependent macaques. (C) qPCR analysis showing expression of APP mRNA in the FC and BG of saline and morphine dependent macaques. N = 4 macaques per group. Data are presented as mean±SEM. Student t test was used to determine the statistical significance between the groups: $P <0.01, *P< 0.05 versus saline. Abbreviations: APP, Amyloid Precursor Protein, Aβ, amyloid β, IL1-β, interleukin, qPCR, quantitative polymerase chain reaction.