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. 2021 Sep 1;12(6):1389–1408. doi: 10.14336/AD.2021.0406

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Copyright: © 2021 Sil et al.

this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 7. — Expression of HIF-1α and BACE1 in the brains of morphine-dependent macaques. Representative western blots showing the expression of HIF-1α and BACE1 in the FC (A) and BG (B) of saline or morphine-dependent macaques. (C) qPCR demonstrating the expression of HIF-1α and BACE1 in the FC (C) and BG (D) of saline or morphine-dependent macaques. n= 4 macaques per group. Data are presented as mean±SEM. Student t test was used to determine the statistical significance between multiple groups: $P< 0.001, ^P< 0.01, *P< 0.05 versus saline. Abbreviations: HIF-1α, hypoxia-inducible factor 1α, qPCR, quantitative polymerase chain reaction.