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. 2021 Sep 1;12(6):1363–1375. doi: 10.14336/AD.2020.0908

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Copyright: © 2021 Muraoka et al.

this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 2. — Proteomic profiling of former NFL players and controls plasma-derived EVs. (A) Upper panel: Particle numbers of Plasma-derived EV fraction from CTRLs and former NFL players by NTA (p = 0.4855 by Mann-Whitney test). Y-axis, log₂ scale. Lower panel: Particle size of Plasma-derived EV fraction (p = 0.9497). (B) Transmission electron microscopy (TEM) image of former NFL player and control plasma-derived EV. Left: Control, Right: former NFL player. Scale bar; 100nm. (C) Venn diagram of the proteins identified in plasma-derived EVs from CTRLs (blue) and former NFL players (red). (D-G) Gene Ontology (GO) analysis using DAVID Bioinformatics Resources 6.8. (D) The GO term of Top 5 Cellular Component with -log₁₀(FDR p-value). (E) The GO term of Top 5 Biological Process with -log₁₀(FDR p-value). (F) The GO term of Top 5 Molecular Function with -log₁₀(FDR p-value). (G) The GO term of Top 5 Disease Ontology with -log₁₀(FDR p-value).