Table 2.

Small EVs (Exosomes) and their microRNA content in MS.

Disease Progression	Dysregulated miRNA	Derived from	Reference
RRMS/SPMS vs HC	Up regulated miR-let-7i, miR-19b, miR-25, miR-92a	Circulating exosomes	(67)
RRMS vs HC	miR-15b-5p, miR-451a, miR-30b-5p, miR-342-3p	Circulating exosomes	(68)
SPMS vs HC	miR-127-3p, miR-370-3p, miR-409-3p, miR-432-5p
RRMS vs SPMS	miR-15b-5p, miR-23a-3p, miR-223-3p, miR-374a-5p, miR-30b-5p, miR-433-3p, miR-485-3p, miR-342-3p, miR-432-5p
RRMS vs HC	Up regulated miR-196b-5p, miR-301a-3p and miR-532-5p	Circulating exosomes	(69)
	Down regulated miR-122-5p, miR-196b-5p, miR-301a-3p, and miR-532-5
MS vs HC	Up regulated miR-146a-5p, miR-181a and miR-223	CSF exosomes	(70)