Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 1;12(6):1409–1422. doi: 10.14336/AD.2021.0621

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © 2021 Kim et al.

this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

PMC Copyright notice

Figure 6. — Inhibition of miR-21 or miR-125b in early-passage iMSCs affects the immunomodulatory function of their EVs. (A-B) After treatment with EVs (0.75 to 3 X10⁹ particles/ml) from P5 iMSCs transfected with control or miR-21/miR-125b inhibitors, levels of IFN-γ, IL-6, IL-17, and TGF-β1 in conditioned medium of LPS-stimulated splenocytes were determined with ELISA. (C) Relative mRNA levels of IFN-γ, IL-6, IL-17 and IL-21 in cocultured human SGECs and PBMCs treated with these EVs (3 X10⁹ particles/ml) were determined with qRT-PCR. All data are presented as means ± SD (n=4). *: p < 0.05, **: p < 0.01, ***: p < 0.001, ****: p < 0.0001 by one-way ANOVA with Dunnett’s test.