Table 2.
Up- and down-regulated brain-derived EV proteins in CTE compared with controls
| Uniprot ID | Gene Name | Control Average a | CTE Average | log2(CTE/Controls) | p value b |
|---|---|---|---|---|---|
| P05408 | SCG5 | 1.062 | 0.786 | -0.435 | 0.0268 |
| P27338 | MAOB | 1.061 | 0.904 | -0.231 | 0.0498 |
| P30101 | PDIA3 | 1.023 | 0.916 | -0.160 | 0.0161 |
| P31946 | YWHAB | 0.579 | 0.449 | -0.368 | 0.0291 |
| P10599 | TXN | 0.983 | 1.083 | 0.140 | 0.0302 |
| P31150 | GDI1 | 0.969 | 1.034 | 0.094 | 0.0279 |
| Q13303 | KCNAB2 | 0.931 | 1.095 | 0.234 | 0.0408 |
| P50991 | CCT4 | 1.135 | 1.389 | 0.291 | 0.0418 |
| Q99747 | NAPG | 1.008 | 1.168 | 0.213 | 0.0392 |
| P19784 | CSNK2A2 | 0.918 | 1.027 | 0.161 | 0.0178 |
| Q9HCH3 | CPNE5 | 0.939 | 1.050 | 0.161 | 0.0313 |
| P45974 | USP5 | 0.916 | 1.071 | 0.225 | 0.0353 |
| Q4G0F5 | VPS26B | 0.985 | 1.117 | 0.183 | 0.0453 |
| Q7Z6L0 | PRRT2 | 0.905 | 1.155 | 0.353 | 0.0184 |
| P60880 | SNAP-25 | 0.981 | 1.065 | 0.119 | 0.0365 |
| Q14194 | CRMP1 | 1.056 | 1.236 | 0.227 | 0.0095 |
| Q2M1P5 | KIF7 | 1.016 | 1.145 | 0.173 | 0.0161 |
| P05023 | ATP1A1 | 1.021 | 1.096 | 0.103 | 0.0409 |
| P09471 | GNAO1 | 0.949 | 1.093 | 0.204 | 0.0389 |
| P28482 | MAPK1 | 0.954 | 1.148 | 0.266 | 0.0204 |
| Q99962 | SH3GL2 | 0.981 | 1.116 | 0.186 | 0.0436 |
| Q01813 | PFKP | 1.086 | 1.235 | 0.186 | 0.0080 |
| P22314 | UBA1 | 0.959 | 1.053 | 0.134 | 0.0167 |
a
The value shows normalized intensity by standard pooled sample.
b
The statistical significance of the differences were calculated using Student’s test.