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. 2021 Sep 1;91:66–76. doi: 10.1016/j.parkreldis.2021.08.018

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — Changes to daily routines and PD-related symptoms during COVID-19 confinement. (A) Map depicting the geographic location of the two provinces included in the study (yellow). The size of the circles is proportional to the number of participants in each province. Information in the yellow squares summarizes the characteristics of the cohorts recruited in Alberta and Québec. (B) Graph showing the cumulative mortality associated with COVID-19 infection in the global population in Alberta (red line) and Québec (blue line) during the survey period (March to September 2020). Census data obtained from provincial sources [46], COVID-19 mortality data obtained from the COVID-19 Canada Open Data Working Group [47]. (C,D) The timeline provides key dates related to COVID-19 confinement in Alberta (C) and Québec (D) and the histograms depict the number of responses to the surveys during the duration of the study with each bar of the histogram corresponding to a specific week. (E,F) Radar chart showing the percentage of self-reported worsening (E) or daily fluctuations (F) in motor and non-motor symptoms in men (blue line) and women (orange line) since COVID-19-related confinement. Each grey line of the axis corresponds to a percentage value. Data analyzed using a Pearson exact Chi-square test with Monte Carlo estimation when necessary, *p ≤ 0.05. Abbreviations: n, number; PD, Parkinson's disease; Sept., September.