In sarcoidosis patients, age, sex, ancestry, and geographical origin and also socio-professional category influencing the respective extrapulmonary localization occurrence.

Planning a correct work-up of pulmonary sarcoidosis diagnosis and during follow-up is essential for detecting extrapulmonary sarcoidosis involvement.

In patients with only extrapulmonary manifestations suggesting sarcoidosis, 18FFDG-PET may show a typical uptake in hilar or mediastinal lymphadenopathy and then one may be able to observe granulomas thanks to EBUS-TBNA.

In a patient diagnosed with sarcoidosis, it is important to balance arguments for and against a link between any extrapulmonary manifestation and sarcoidosis.

Severe cardiac, neurological, renal, and eye localizations can be seen at sarcoidosis onset, while cardiac or renal localizations may also appear later.

Extrapulmonary sarcoidosis care is based on disease-modifying drugs, organ-directed treatments, and supportive treatments to improve organ dysfunction risks and quality of life, and needs to be holistic, personalized, and in line with patient expectations.