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. 2021 Aug 8;38(9):4872–4884. doi: 10.1007/s12325-021-01853-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 3 — Indirect comparison of rVIII-SingleChain versus rFVIIIFc for a estimated mean ABR^†, b percentage of patients with zero bleeds and c mean annualized rFVIII consumption, before and after matching. ^†Estimated by negative binomial regression model. ^‡(Total rFVIIIFc IU/kg received during the efficacy period/number of days in efficacy period) × 365.25. P values for comparisons after matching were 0.32 for ABR, 0.35 for percentage of patients with zero bleeds and 0.85 for annualized rFVIII consumption. ABR annualized bleeding rate, CI confidence interval, rFVIII recombinant factor VIII